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School of Medicine Columbia

Histology

Histology, the study of tissues at a microscopic level, unveils the intricate architecture of biological structures within organisms. Utilizing specialized staining and imaging techniques, histology enables the investigation of cellular composition, organization, and function, providing essential insights into the fundamental building blocks of living organisms.

Equipment Options

With the ability to store and run up to 15 different user defined staining protocols in a high-throughput system maintaining up to 11 racks of 30 slides, the Leica Autostainer XL provides reproducible, consistent high-quality staining, and increased workload throughput compared to manual staining.

Location

IRF B60

IRF Contact

Karmen Owen

The semi-automated Leica VT1200 S vibrating blade microtome is designed for sectioning fresh specimen. Designed for users who prefer to manually control sectioning parameters such as section thickness and cutting, this vibratome maintains magnetic specimen holders for easy specimen handling and reproducible orientation in addition to a minimal vertical deflection that minimizes specimen damage during sectioning and results in more viable cells on the section surface.

Location

IRF B60

IRF Contact

Karmen Owen

The Reichert Jung 2030, a unique high-performance microtome that features high precision and reproducible quality sections from wax and plastic embedded samples, is a proven microtome that can be used in nearly all fields of histological techniques from biology to industry.

Location

IRF B60

IRF Contact

Karmen Owen

The Thermo Scientific HM525 Cryostat is a high-performance routine cryostat that delivers high-quality, high-throughput results comfortably and efficiently.

Location

IRF B60

IRF Contact

Karmen Owen

The X-CLARITY™ Polymerization System is a standalone, automated system developed to simplify tissue-hydrogel hybridization, a crucial step for optimal tissue clearing. Multiple samples can be placed in multi-well plates or conical tubes for rapid and efficient high-throughput sample processing. Users can control polymerization by adjusting vacuum strength, temperature, and a timer through a simple touchscreen interface.

The X-CLARITY™ Tissue Clearing System is an all-in-one, easy-to-use solution for electrophoretic tissue clearing. Its unique design accelerates the removal of lipids from tissues while preserving the structural integrity of the sample. A built-in temperature control system actively cools and heats buffer to maintain consistent buffer temperatures during clearing. Buffer is constantly circulated to ensure consistent buffering capacity, temperature control, and elimination of tissue clearing byproducts. This advanced system ensures efficient, rapid, and consistent tissue clearing.

Location

IRF B59

IRF Contact

Anna Harper

The Leica ASP300 tissue processor is designed for smart paraffin infiltration of tissue. Straightforward routine user operations and a variety of ‘Smart’ features, such as the Reagent Management System (RMS) and quick start for commonly used programs, improve specimen quality and laboratory economy.

Location

IRF B60

IRF Contact

Karmen Owen

The Leica CV5000 is designed to coverslip microscope glass slides bearing tissue sections or cytopathology smears at a high-throughput volume of up to 400 slides per hour. The Leica CV5000 can be operated in either batch or single slide modes and is compatible with both glass slides and glass coverslips from a wide variety of manufacturers. Coverslips are precisely separated during processing and dispensed one at a time. Operation is easy to learn with simple loading and unloading features and only three push buttons necessary for operation. An automatic detection system identifies broken slides and disposes of them in a catcher.

Location

IRF B60

IRF Contact

Karmen Owen

The Tanner TN-1550 Tissue Embedding Center and cooling plate are used to embed pathological tissue. It is also used to cool the tissue or zoological and botanical tissues after embedding. The advanced control-microprocessor and new PTC calorific material have been applied to this machine. It has functions of temperature control located on 5 parts, and multiple over-heat protection devices. Users can decide time of power on/off by functions of timing power on/off and preset time of the week. Tissue embedding can immediately commence as soon as the paraffin block melts.

Location

IRF B60

IRF Contact

Karmen Owen

The TEC™-II innovative microprocessor technology ensures dependability and performance that requires less space as well as a low work surface to reduce user fatigue and maximize workflow efficiencies.

Location

IRF B60

IRF Contact

Karmen Owen

This module offers consistent antigen retrieval for high quality immunohistochemistry. Using gentle heat, the retrieval device quickly produces outstanding results while maintaining the integrity of delicate tissue. In addition, most users can streamline testing practices by consolidating various antigen retrieval methods into only one or two PT Module antigen retrieval device procedures that can be run simultaneously. Precise temperature control without the damaging effects of temperature variations, microwaves or pressure delivers a level of consistency unmatched by any other instrument available.

Location

IRF B60

IRF Contact

Karmen Owen

The Leica RM2255 Microtome effortlessly transitions between motorized and manual sectioning, guaranteeing the reproducibility of high-quality sections. The intuitive touch control panel enhances user efficiency, while safety and precision harmonize through features like Knife Holder E and an ergonomic handwheel. Abundant storage and optional cooling further enhance its capabilities. Powered by Leica’s proven technology, including a patented gravitational force compensation system and precise micrometer feed, the RM2255 sets new standards. It’s the microtome of choice for laboratories seeking exceptional control, versatility, and safety.

Location

IRF B60

IRF Contact

Karmen Owen




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