Background

1982-1986 Wartburg College – Bachelors of Arts, Biology & Chemistry
1987-1991 University of Iowa – Ph.D. – Anatomy & Cell Biology

Research

The focus of the Potts lab is to use the principles of developmental biology and marriage it to regenerative medicine. Millions of people suffer from a vast assortment of diseases and complications that are now treated with new regenerative medicine therapies. The goal of the lab’s research is to develop biocompatible tissues and treatments for numerous diseases and pathologies. Heart valves, cartilage, bone, cornea and wound healing are examples of the tissues our lab studies. Furthermore, we have incorporated the use of mesenchymal stem cells, which provide the necessary cellular component to create these in vitro constructs. As a result, the development of biocompatible tissues using the host’s own cells will be designed and created to help repair and remodel various defects.

Teaching

• Moore K, Vandergriff A, Potts JD (2013) Microencapsulation of stem cells to study cellular interactions. Methods Mol Biol 1066:113-120.
• Moore K, Bryant, ZJ, Ghetnekar, G., Singh, UP, Amos J, Davis J, Gourdie R, Potts JD. 2013. A Synthetic Connexin 43 Mimetic Peptide Augments Corneal Wound Healing. Exp. Eye Res. In Press.
• Moore K, Ghetnekar, G, Gourdie R, Potts JD. 2013. Impact of the Controlled Release of a Connexin 43 Peptide on Corneal Wound Closure in an STZ Model of Type I Diabetes. PLOS 1, In Press.
• Li N, Goodwin RL, Potts JD. 2013. Zyxin regulates cell migration and differentiation in EMT during chicken AV valve morphogenesis. Microsc Microanal 7:1-13.
• Moore K, Amos J, Davis J, Gourdie R, Potts JD. 2013. Characterization of polymeric microcapsules containing a low molecular weight peptide for controlled release. Microsc Microanal. 19:213-26
• Gourdie, RG, Myers, TA, McFadden, A, Li, Y-X, Potts, JD. 2011. Self-Organizing Tissue-Engineered Constructs in Collagen Hydrogels. Microscopy and Microanalysis.
• Valarmathi MT, Fuseler, J, Goodwin RL, Potts JD. 2011. The Mechanical Coupling of Adult Marrow Stromal Stem Cells During Cardiac Regeneration Assessed in a 2-D Co-Culture Model. Biomaterials. 32(11): 2834-50.
• Tan, H, Junor, L, Norris, RA, Price, RL, Potts, JD, Goodwin, RL. 2010. Expression and deposition of fibrous extracellular matrix proteins in cardiac valves during chick development. Microscopy and Microanalysis. 17(1): 91-100.
• Valarmathi MT, Davis, J, Yost MJ, Goodwin RL, Potts JD. 2010. Development of a 3-D cardiac muscle construct to explore adult stem cell based myocardial regeneration. Biomaterials. 31(12): 3185-200
• Ichikawa T, Li J, Dong X, Potts JD, Tang DQ, Li DS, Cui T. 2010. Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation. Biochem Biophys Res Commun. 391(1): 852-56.
• Kaur, F, Valarmathi, M., Potts, JD., Sabo-Attwood, T., Wang, Q. 2010. Regulation of Osteogenic Differentiation of Rat Bone Marrow Stromal Cells on 2D Nano-Rod Substrates. Biomaterials, 31(7): 1732-41.
• Biechler, SV.,  Potts, JD., Yost, MJ., Junor, L., Goodwin,  RL., and Weidner, JW. 2010. Mathematical Modeling of Flow-Generated Forces in an In Vitro System of Cardiac Valve Development. Ann of Biomed Engineering. 38:109-117.
• Amos, JR, Li, S, Yost, MJ, Ploehn, HJ, Potts, JD. 2010. Limb bud mesenchyme cultured under tensile strain produce a cartilage like tissue in culture.  Biorheology. 46(6): 439-50.
• Norris, RA, Potts, JD, Yost, MJ, Junor, L, Brooks, T, Tan, H, Hoffman, S, Hart, MM, Damon, B, Markwald, RR, Goodwin, RL. 2009. Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cells. Dev. Dyn. 238:1052-1063.
• Goldsmith, E, A Hoffman, A Jacobs, JP Watson and JD Potts.  2009.  The collagen receptor DDR2 is a marker for the transformed phenotype produced during cardiac epithelial-mesenchymal cell transformation.  Anatomical Record.  293(5):762-69.

Find Dr. Jay Potts on PubMed»