Education

Dr. Jay Potts is a native Iowan who received his B.A. in Biology and Chemistry from Wartburg College, Waverly IA. He then went to the University of Iowa and obtained his Ph.D. in the department of Cell Biology and Anatomy under the guidance of Drs. Ray Runyan and Dan Weeks. In their labs he studied the molecules that regulate embryonic heart valve formation discovering the role of TGFß in heart development. Following his Ph.D., he completed another 5 years of postdoctoral training at the Uniformed Services University, Bethesda, MD. working in the laboratory of Dr. David Beebe. There he studied the molecular regulation of embryonic lens development. Dr. Potts is a Professor in the Cell Biology and Anatomy Department at the UofSC School of Medicine.

Research Interests

As a developmental biologist trained in the regulation of early embryonic development, Dr. Potts has a long-standing and keen interest in the molecular regulation of cardiac and ocular development. This led to the creation of several unique models recapitulating key aspects of cardiac valve and lens development and disease. An offshoot of this work has centered on the use of stem cells and the cues necessary to mimic in vivo developmental processes. His recent work has centered on new peptidergic therapies and their delivery to treat a myriad of diseases including heart failure (HF) and retinitis pigmentosa (RP). Dr. Potts has an active lab with undergraduate, graduate and medical students all working on various aspects of these projects.

Biography

Dr. Potts has technical expertise in a wide array of molecular, cellular and proteomic experimental approaches using both in vitro and in vivo models. He is particularly well-versed in Real Time PCR, image analysis and has extensive experience with the BioRad and Thermo line of RTPCR   and Licor Odyssey machines. Because of his skills in these areas, he serves as the Director of the Genomics and Proteomics Core at the UofSC School of Medicine Instrumentation Resource Facility (IRF). Dr. Potts is also the course director for 2 of the core courses taught in the Biotechnology MS program headed by the IRF. Dr Potts has been affiliated with the IRF for more than a decade and is the Associate Director of the IRF serving under the Director Dr. Austin Worden.

Other

When he is not at work, Jay is a father of two grown boys. His hobbies include staying active by golfing, biking, hiking and working out.

Publications

• Moore K, Vandergriff A, Potts JD (2013) Microencapsulation of stem cells to study cellular interactions. Methods Mol Biol 1066:113-120.
• Moore K, Bryant, ZJ, Ghetnekar, G., Singh, UP, Amos J, Davis J, Gourdie R, Potts JD. 2013. A Synthetic Connexin 43 Mimetic Peptide Augments Corneal Wound Healing. Exp. Eye Res. In Press.
• Moore K, Ghetnekar, G, Gourdie R, Potts JD. 2013. Impact of the Controlled Release of a Connexin 43 Peptide on Corneal Wound Closure in an STZ Model of Type I Diabetes. PLOS 1, In Press.
• Li N, Goodwin RL, Potts JD. 2013. Zyxin regulates cell migration and differentiation in EMT during chicken AV valve morphogenesis. Microsc Microanal 7:1-13.
• Moore K, Amos J, Davis J, Gourdie R, Potts JD. 2013. Characterization of polymeric microcapsules containing a low molecular weight peptide for controlled release. Microsc Microanal. 19:213-26
• Gourdie, RG, Myers, TA, McFadden, A, Li, Y-X, Potts, JD. 2011. Self-Organizing Tissue-Engineered Constructs in Collagen Hydrogels. Microscopy and Microanalysis.
• Valarmathi MT, Fuseler, J, Goodwin RL, Potts JD. 2011. The Mechanical Coupling of Adult Marrow Stromal Stem Cells During Cardiac Regeneration Assessed in a 2-D Co-Culture Model. Biomaterials. 32(11): 2834-50.
• Tan, H, Junor, L, Norris, RA, Price, RL, Potts, JD, Goodwin, RL. 2010. Expression and deposition of fibrous extracellular matrix proteins in cardiac valves during chick development. Microscopy and Microanalysis. 17(1): 91-100.
• Valarmathi MT, Davis, J, Yost MJ, Goodwin RL, Potts JD. 2010. Development of a 3-D cardiac muscle construct to explore adult stem cell based myocardial regeneration. Biomaterials. 31(12): 3185-200
• Ichikawa T, Li J, Dong X, Potts JD, Tang DQ, Li DS, Cui T. 2010. Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation. Biochem Biophys Res Commun. 391(1): 852-56.
• Kaur, F, Valarmathi, M., Potts, JD., Sabo-Attwood, T., Wang, Q. 2010. Regulation of Osteogenic Differentiation of Rat Bone Marrow Stromal Cells on 2D Nano-Rod Substrates. Biomaterials, 31(7): 1732-41.
• Biechler, SV.,  Potts, JD., Yost, MJ., Junor, L., Goodwin,  RL., and Weidner, JW. 2010. Mathematical Modeling of Flow-Generated Forces in an In Vitro System of Cardiac Valve Development. Ann of Biomed Engineering. 38:109-117.
• Amos, JR, Li, S, Yost, MJ, Ploehn, HJ, Potts, JD. 2010. Limb bud mesenchyme cultured under tensile strain produce a cartilage like tissue in culture.  Biorheology. 46(6): 439-50.
• Norris, RA, Potts, JD, Yost, MJ, Junor, L, Brooks, T, Tan, H, Hoffman, S, Hart, MM, Damon, B, Markwald, RR, Goodwin, RL. 2009. Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cells. Dev. Dyn. 238:1052-1063.
• Goldsmith, E, A Hoffman, A Jacobs, JP Watson and JD Potts.  2009.  The collagen receptor DDR2 is a marker for the transformed phenotype produced during cardiac epithelial-mesenchymal cell transformation.  Anatomical Record.  293(5):762-69.

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