Education

Training

• Massachusetts General Hospital, Harvard Medical School, Boston
• Tulane University Medical School, Dept. of Medicine, and VA Medical Center, Endocrine, Polypeptide and Cancer Institute, New Orleans

Education

• Anatomic Pathology Residency, Athens, Greece
• PhD, Medical School, University of Athens, Greece
• MD, Medical School, University of Athens, Greece
• BS, Dept. of Biology, University of Athens, Greece

Research Interests/Areas of Expertise

Dr. Chatzistamou possesses considerable experience in diagnostic surgical pathology including but not limited to GI, female genital tract, breast, lung, prostate, and head and neck. She also holds significant expertise in experimental pathology primarily related to the characterization of xenografts and transgenic/mutant mouse cancer models, and pre-clinical models of non-neoplastic conditions such as autoimmune, metabolic diseases, and tissue regeneration. Her postdoctoral training at Tulane University in the group of Nobel laureate Prof. A.V. Schally allowed her to perform bench research in experimental and neuroendocrine oncology/pathology. Dr. Chatzistamou's current interests focus on pre-clinical model characterization for pathologies, such as cancer, inflammation, and autoimmune and metabolic disorders. She is also interested in the use and characterization of non-traditional rodent species, such as outbred deer mice, as models for various pathological conditions.

Selected Publications

• Haghani A…. Chatzistamou I…. Horvath S. (Methylation Consortium; 190 authors). DNA Methylation Networks Underlying Mammalian Traits. Science, Aug 11;381(6658):eabq5693. doi: 10.1126/science.abq5693, 2023
• Lu A, …. Chatzistamou I…. Horvath S. (Methylation Consortium; 190 authors). Universal DNA methylation age across mammalian tissues. Nature Aging. Aug 10. doi: 10.1038/s43587-023-00462-6, 2023
• Saatci O, Cetin M, Uner M, Tocat U, Chatzistamou I, Ersan P, Montaudon E, Akyol A, Aksoy S, Uner A, Marangoni E, Sajish M, Sahin O. Toxic PARP trapping upon cAMP-induced DNA damage reinstates the efficacy of endocrine therapy and CDK4/6 inhibitors in treatment-refractory ER+ breast cancer. Nature Communications,14(1):6997, 2023

• Mohammed AD, Mohammed Z, Roland MM, Chatzistamou I, Jolly A, Schoettmer LM, Arroyo M, Kakar K, Tian Y, Patterson A, Nagarkatti M, Nagarkatti P, Kubinak JL. Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel. Nature  Communications, 13(1):525; 2022
• Zhang Y, Lim C, Sikirzhytski V, Naderi A, Chatzistamou I and Kiaris H. The propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain. Disease Models & Mechanisms.14(10), 2021
• Horvath S, Haghani A, Zoller JA, Naderi A, Soltanmohammadi E, Farmaki E, Kaza V, Chatzistamou I,Kiaris H. Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy. GeroScience Feb;44(1):447-461. doi: 10.1007/s11357-021-00472-5, 2021
• Naik H, Sonju JJ, Singh S, Chatzistamou I, Shrestha L, Gauthier T, Jois S. Lipidated Peptidomimetic Ligand-Functionalized HER2 targeted liposome as Nano-Carrier designed for Doxorubicin delivery in cancer therapy. Pharmaceuticals (Basel),14(3):221, 2021

• Naderi A, Soltanmaohammadi E, Kaza V, Barlow S, Chatzistamou I, Kiaris H. Persistent effects of pair bonding in lung cancer cell growth in monogamous Peromyscus californicus. Elife 10:e64711, 2021
• Becker W, Alrafas HR, Wilson K, Miranda K, Culpepper C, Chatzistamou I, Cai G, Nagarkatti M, Nagarkatti PS. Activation of cannabinoid receptor 2 prevents colitis-associated colon cancer through myeloid cell de-activation upstream of IL-22 production. iScience. 27;23(9):101504, 2020
• Milovic A, Bassam K, Shao H, Chatzistamou I, Tufts DM, Diuk-Wasser M, Barbour AG. Lactobacilli and other gastrointestinal microbiota of Peromyscus leucopus, reservoir host for agents of Lyme disease and other zoonoses in North America. PLoS One,15(8):e0231801, 2020
• Farmaki E, Kaza V, Chatzistamou I, Kiaris H. CCL8 promotes postpartum breast cancer by recruiting M2 macrophages. iScience 23 (6):101217, 2020
• Feng M, Kim J, Field K, Reid C, Chatzistamou I, Shim M. Aspirin ameliorates the long-term adverse effects of doxorubicin through suppression of cellular senescence. FASEB BioAdvances, 1:579-590, 2019
• Chatzistamou I, Farmaki E, Kaza V, Kiaris H. The value of outbred rodent models in cancer research. Trends in Cancer. 4(7)487-496; 2019
• Kiaris H, Chatzistamou I. Inhibition of tumor growth by agonists of growth hormone-releasing hormone. Proc Natl Acad Sci USA, 115(47): 11876-11878; 2018