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College of Pharmacy

Faculty and Staff

Chao Cai, Ph.D.

Title: Assistant Professor
Department: Clinical Pharmacy and Outcomes Sciences (CPOS)
College of Pharmacy
Phone: 803-777-2333
Office: College of Pharmacy
715 Sumter Street - CLS 311H
Columbia, SC 29208
Chao Cai portrait


Ph.D.  Biostatistics, University of South Carolina, 2013


Chao Cai, Ph.D. is an assistant professor in the Department of Clinical Pharmacy and Outcomes Sciences at the University of South Carolina College of Pharmacy in Columbia, South Carolina.

Dr. Cai received her masters degree in Applied Statistics from University of Pittsburgh in 2003 and Ph.D. in Biostatistics from the University of South Carolina in 2013. Her areas of expertise include applying advanced statistical methods in outcomes sciences and providing statistical consulting in collaborative research.

Research Interests

  • Survival Analysis
  • Mediation Analysis
  • Predictive Models
  • Clinical Trials
  • Medication Adherence and Persistence Analysis
  • Statistical Design and Analysis in Health Sciences


Cai C, Love BL, Yunusa I, Reeder CE. Applying mixture cure survival modeling to medication persistence analysis. Pharmacoepidemiology and Drug Safety. 2022;1‐8. doi:10.1002/pds.5441. PubMed PMID: 35426193 .

Cai C, Yunusa I, Tarhini A. Estimated Cost-effectiveness of Atezolizumab Plus Cobimetinib and Vemurafenib for Treatment of BRAF V600 Variation Metastatic Melanoma. JAMA Netw Open. 2021 Nov 1;4(11):e2132262. doi: 10.1001/jamanetworkopen.2021.32262. PubMed PMID: 34762112; PubMed Central PMCID: PMC8586909.

Yunusa I, Love BL, Cai C, Hastings T, Reeder CE, Blake EW, Phillips C. Trends in Insulin Prescribing for Patients With Diabetes During the COVID-19 Pandemic in the US. JAMA Netw Open. 2021 Nov 1;4(11):e2132607. doi: 10.1001/jamanetworkopen.2021.32607. PubMed PMID: 34730822; PubMed Central PMCID: PMC8567113.

Prinz RJ, Metzler CW, Sanders MR, Rusby JC, Cai C. Online-delivered parenting intervention for young children with disruptive behavior problems: a noninferiority trial focused on child and parent outcomes. J Child Psychol Psychiatry. 2021 Apr 8;. doi: 10.1111/jcpp.13426. PubMed PMID: 33829499.

Shealy K, Phillips C, Bzowyckyj A, Gupta V, Guyton J, Westberg S, Cai C, Trujillo J, Goldman J. Endocrine pharmacotherapy education in United States colleges and schools of pharmacy. J Am Coll Clin Pharm. 2021; 4: 481– 489.

Wang Y, Zhang J, Cai C, Lu W, Tang Y. Semiparametric estimation for proportional hazards mixture cure model allowing non-curable competing risk. Journal of Statistical Planning and Inference. 2020 June.

Fairchild A, Cai C, McDaniel H, Shi D, Gottschall A, Masyn K, Evaluating A method to Estimate Mediation Effects with Discrete-Time Survival Outcomes. Frontiers in Psychology, Quantitative Psychology and Measurement, 05 April, 2019

Cai C, Wang S, Lu W, Zhang J, NPHMC: An R-Package for estimating sample size of proportional hazards mixture cure models, Computer Methods and Programs in Biomedicine, 113: 290-300, 2014

Cai C, Zou Y, Peng Y, Zhang J, smcure: An R-Package for estimating semiparametric mixture cure models, Computer Methods and Programs in Biomedicine, 108:1255–1260, 2012

Tarhini A, Kirkwood M, Gooding W, Cai C, Agarwala S. Durable Complete Responses With High-Dose Bolus Interleukin-2 in Patients With Metastatic Melanoma Who Have Experienced Progression After Biochemotherapy. Journal of Clinical Oncology, 25, 3802-3807, 2007

Akhavan A, Keith D, Bastacky I, Cai C, Wang Y, Nelson B. The proportion of cores with high-grade prostatic intraepithelial neoplasia on extended-pattern needle biopsy is significantly associated with prostate cancer on site-directed repeat biopsy. BJU International, 99, 765-769, 2007

Patel H, Stoller R, Auber M, Potter D, Cai C, Zamboni W, Kiefer G, Matin K, Schmotzer A, Ramanathan R. Phase II Study of Rubitecan an Oral Camptothecin in Patients with Advanced Colorectal Cancer Who Have Failed Previous 5-Fluorouracil based Chemotherapy. Investigational New Drugs, 24, 359-363, 2006

Gologan A, Bastacky S, McHale T, Yu J, Cai C, Monzon F, Dhir R. Age-associated changes in Alpha-methyl CoA racemase (AMACR) expression in non-neoplastic prostatic tissues. American Journal of Surgical Pathology, 29, 1435-1441, 2005

Modugno F, Zmuda JM, Potter D, Cai C, Ziv E, Cummings S, Stone KL, Morin PA, Greene D, Cauley JA. The Association of Estrogen Receptor Alpha Polymorphisms with Breast Cancer. Risk in Older White Women. International Journal of Cancer, 116, 984-991, 2005

Modugno F, Zmuda JM, Potter D, Cai C, Ziv E, Cummings S, Stone KL, Morin PA, Greene D Cauley JA. Estrogen Metabolizing Polymorphisms and Breast Cancer Risk among Older White Women. Breast Cancer Research and Treatment, 93, 261-70, 2005

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