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College of Engineering and Computing

Faculty and Staff

James Otto Blanchette

Title: Instructor
Department: Biomedical Engineering
College of Engineering and Computing
Phone: 803-777-0926
Fax: 803-777-0106

Room A213

300 Main Street

Columbia, SC 29208

Experience and Education

Instructor and Research Specialist III, Biomedical Engineering, 2015-Present
Research Assistant Professor, College of Engineering and Computing, University of South Carolina, 2014
Assistant Professor, Chemical Engineering, University of South Carolina, 2007-2013
Research Associate, Howard Hughes Medical Institute, 2004-2007
PhD, Biomedical Engineering, University of Texas, 2004
Cancer Research Training Award, National Cancer Institute, 1998-2000
BS, Biomedical Engineering, Duke University, 1998


My research interests fall into the areas of: design of cell-instructive materials, delivery of therapeutics and tissue engineering. Specific projects include: developing responsive delivery systems to expand the spectrum of chemotherapeutics which can be administered orally; extending proper function of pancreatic islet cells following transplantation through genetic engineering and design of instructive hydrogel materials; tracking hypoxic signaling in three-dimensional cell aggregates; and transplantation of mesenchymal stem cells to enhance vascularization.

Selected Publications

Skiles M L, Hanna B, Rucker L, Tipton A, Brougham-Cook A and Blanchette J O. ASC spheroid geometry and culture oxygenation differentially impact induction of pre-angiogenic behaviors in endothelial cells. Cell Transplantation, 24(11), 2323-35, 2015).

Skiles M L, Sahai S, Rucker L and Blanchette J O. Use of culture geometry to control hypoxia-induced VEGF secretion from ADSCs: optimizing a cell-based approach to drive vascular growth. Tissue Eng Part A, 19(21-22), 2330-8, (2013).

Sahai S, Williams A, Skiles M L and Blanchette J O. Osteogenic differentiation of adipose-derived stem cells is HIF-1 independent. Tissue Eng Part A, 19(13-14), 1583-91, (2013).

Sahai S, McFarland R, Skiles M L, Sullivan D, Williams A and Blanchette J O. Tracking hypoxic signaling in encapsulated stem cells. Tissue Eng Part C Methods, 18(7), 557-565, (2012).

Brannon-Peppas L and Blanchette J O. Nanoparticles and targeted systems for cancer therapy. Adv Drug Del Rev, 56, 1649-1659, (2004).


BMEN 101 – Introduction to Biomedical Enigneering
BMEN 211 – Computational Toold for Modeling of Biomedical Systems
BMEN 212 – Fundamentals of Biomedical Systems
BMEN 271 – Introduction to Biomaterials
BMEN 290 – Thermodynamics of Biomolecular Systems
BMEN 546 – Delivery of Bioactive Agents

Honors and Awards

Promising Investigator Award (University of South Carolina)
“Nanoparticle and targeted systems for cancer therapy” selected for 25th anniversary edition of Advanced Drug Delivery Reviews. Recognized as one of the most highly cited articles in the journal’s history.
Capsugel Grand Prize (from Controlled Release Society) – International award for outstanding research in oral drug delivery by graduate student/postdoc
Geddes-Laufman-Greatbatch Award (Purdue University) – The outstanding Biomedical Engineering graduate student
Outstanding Research Award (from Biomedical Engineering Society)


Challenge the conventional. Create the exceptional. No Limits.