The success of tissue engineering strategies critically depends on the rapid formation of a mature vascular network in the scaffolds after implantation. Relying on infiltration of vessels into the scaffold after implantation has not been successful to date. Blood vessels from the surrounding host tissue initially invade a superficial distance in the constructs. Conventional methods to accelerate the infiltration of host vasculature into the scaffolds rely on incorporation of angiogenic growth factors as well as mature or precursor endothelial cells in the scaffolds. These approaches, however, have demonstrated limited success due to the failure to control the distribution of factors and the inability to extend viability of transplanted cells. In addition, current vascularization paradigms fail to mimic the physiology and solely rely on newly formed capillaries to grow in and form mature blood vessels. Host inflammatory response is another key regulator of angiogenesis factors, which is often neglected in conventional vascularization approaches. Inflammation is the process by which the body protects itself from intruders, and if left uncontrolled, potentially interferes with the integration of implanted biomaterials. The goal of this study is to harness the potential of inflammatory response to enhance directed angiogenesis and osteointegration of three dimensional scaffolds for bone repair.
- K. Rutledge, Cheng G., M. V. Pryzhkova, Harris, and E. Jabbarzadeh, Tissue Engineering 20(11): 865-874 (2014).
- G. Harris, K. Rutledge, and E. Jabbarzadeh, Current Pharm. Des. 19(19): 3456-65 (2013).
- Q Cheng, K. Rutledge, E. Jabbarzadeh, Annals of Biomedical Engineering 41(5) 904-16 (2013).