CHDs are the leading cause of birth defect related deaths and affect one out of a hundred births. My work is aimed at discovering mechanisms that drive cardiac development and how deviations in normal stimulation can lead to diagnosed and undiagnosed pathologies. In particular, I’m interested in the impact that blood flow and mechanics have on influencing stem cell migration and the epithelial-mesenchymal transformation (EMT). These processes are crucial in the development of the greater vessels and cardiac valves. For example, the sparse deposition of elastic fibers in the aorta can lead to aortopathies and future life-threatening aortic aneurysms. More importantly, we are currently exploring the potential to rescue and restore healthy phenotypes from these diseased states. Much of this work depends on our ability to measure blood flow and tissue properties at the micron level using ultrasound coupled with computational-fluid-dynamics (CFD) modeling.
- Menon, V., Eberth, J., Goodwin, R., Potts, J., 2015. Altered Hemodynamics in the Embryonic Heart Affects Outflow Valve Development. J. Cardiovasc. Dev. Dis. 2, 108–124.
- Biechler, S. V, Junor, L., Evans, A.N., Eberth, J.F., Price, R.L., Potts, J.D., Yost, M.J., Goodwin, R.L., 2014. The impact of flow-induced forces on the morphogenesis of the outflow tract. Front. Physiol. 5, 225.
- Menon V, Marwa B, Eberth JF, Potts JD. A novel ex ovo banding technique to alter intracardiac hemodynamics in an embryonic chicken system. JoVE. In Review.