Faculty and Staff
|Title:||Chair, Cell Biology and Anatomy
Professor, Cell Biology and Anatomy, Biomedical Engineering
|Department:||School of Medicine, Biomedical Engineering
College of Engineering and Computing
School of Medicine Bldg 1
Professor, Department of Cell Biology and Anatomy, University of South Carolina, 2012-present
Associate Professor, Department of Cell Biology and Anatomy, University of South Carolina, 2000-2012
Assistant Professor, Department of Cell Biology and Anatomy, University of South Carolina, 1993-2000
PhD, Biological Sciences, University of South Carolina, 1988
BS, Biology, University of South Carolina at Aiken, 1983Ph. D., Biology, University of South Carolina, 1988
M.S., Biology, University of South Carolina, 1985
B.S., Biology, University of South Carolina, Aiken, 1983
The ventricular wall of the heart is composed of contractile muscle cells and non-muscle cell types including fibroblasts, endothelial cells and others. These cells are interconnected and supported by an elaborate extracellular matrix. Changes in the density and organization of the extracellular matrix are known to affect cardiovascular performance and have been correlated with heart disease. For instance, excessive accumulation of extracellular matrix or fibrosis is commonly associated with hypertension and myocardial infarction. Increased accumulation of extracellular matrix as seen during fibrosis results in a “stiffer” myocardium, which alters heart function. The extracellular matrix in the heart is produced largely by cardiac fibroblasts.
The research in Dr. Carver’s lab is focused on understanding how fibroblast behavior and gene expression are regulated in the heart. We are particularly interested in how chronic exposure to alcohol as seen during alcohol abuse results in myocardial fibrosis. Cell culture and animal models are being used to examine the regulation of fibroblasts in cardiovascular disease.
- Carver W, Goldsmith EC (2013) Regulation of tissue fibrosis by the biomechanical environment. Biomed Res Int 2013:101979.Law BA, Carver WE (2013) Activation of cardiac fibroblasts by ethanol is blocked by TGF-beta inhibition. Alcohol Clin Exp Res 37:1286-1294.
- Fowlkes V, Clark J, Fix C, Law BA, Morales MO, Qiao X, Ako-Asare K, Goldsmith JG, Carver W, Murray DB, Goldsmith EC (2013) Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts. Life Sci 92:669-676.
- Fowlkes V, Wilson CG, Carver W, Goldsmith EC(2013) Mechanical loading promotes mast cell degranulation via RGD-integrin dependent pathways. J Biomech 46:788-795.
- Law BA, Levick SP, Carver WE (2012) Alterations in cardiac structure and function in a murine model of chronic alcohol consumption. Microsc Microanal 18:453-461.
MCBA D602 - Medical Microscopic Anatomy
HGEN 725 – Human Developmental Biology
BMEN 589 – Cardiovascular System: From Development to Disease