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College of Pharmacy

Faculty and Staff

Jing Fang, M.D., Ph.D.

Title: Assistant Professor
Department: Drug Discovery & Biomedical Sciences (DDBS)
College of Pharmacy
Email: fang8@cop.sc.edu
Phone: 803-777-2344
Office: College of Pharmacy
715 Sumter Street - CLS 301
Columbia, SC 29208
Jing Fang portrait

Background

M.D. / Ph.D.  Genetics, Shanghai Second Medical University, 2004
M.S.  Immunology, Shandong Academy of Medical Sciences, 2001
B.S.  Clinical Medicine, Taishan Medical University, 1998

Postdoctoral Fellowship 
Hematopoiesis and hematologic malignancies, Maine Medical Center Research Institute, 2009
Cincinnati Children’s Hospital Medical Center, 2016

Research Interests

Hematopoiesis is a highly hierarchical process that multipotential hematopoietic stem cells (HSCs) give rise to all the mature blood cells. My research is to understand the molecular mechanisms governing hematopoiesis with animal models, and how dysregulated signaling pathways in HSC may drive hematological malignancies with a focus on myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). My laboratory is currently studying on two molecules, an adaptor protein sequestosome 1 (also known as p62) and a G protein-coupled receptor GPR68, and their functions in hematopoiesis, HSC function and leukemogenesis. Our long-term goal is to uncover novel mechanisms driving malignant hematopoiesis and identify novel therapeutic targets of hematological malignancies.

Selected Publications

Fang J, Muto T, Kleppe M, Bolanos LC, Hueneman KM, Walker CS, Sampson L, Wellendorf AM, Chetal K, Choi K, Salomonis N, Choi Y, Zheng Y, Cancelas JA, Levine RL, Starczynowski DT. Cell Reports, 2018 Jan 30;22(5):1250-1262. PMID: 29386112

Fang J, Bolanos L, Choi K, Liu X, Christie S, Akunuru S, Kumar R, Wang D, Chen X, Greis K, Stoilov P, Filippi M, Maciejewski J, Garcia-Manero G, Weirauch M, Salamonis N, Geiger H, Zheng Y, Starczynowski D. Ubiquitination of a spliceosome auxiliary factor by TRAF6 links chronic innate immune signaling with hematopoietic defects and myelodysplasia. Nature Immunology, 2017 Mar 22;18(4):474. PMID: 28024152

Fang J, Liu X, Bolanos L, Barker B, Rigolino C, Cortelezzi A, Oliva EN, Cuzzola M, Grimes HL, Fontanillo C, Komurov K, MacBeth K, Starczynowski DT. A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes. Nature Medicine, 2016 Jul;22(7):724-34. PMID: 27294874

Fang J, Barker B, Bolanos L, Liu X, Jerez A, Makishima H, Christie S, Chen X, Rao DS, Grimes HL, Komurov K, Weirauch MT, Cancelas JA, Maciejewski JP, Starczynowski DT. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-kB gene network. (2014). Cell Reports, 2014 8: 1328-38. PMID: 25199827

Fang J, Rhyasen G, Bolanos L, Rasch C, Varney M, Wunderlich M, Goyama S, Jansen G, Cloos J, Rigolino C, Cortelezzi A, Mulloy JC, Oliva EN, Cuzzola M, Starczynowski DT. Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. (2012). Blood, 120(4): 858-67. PMID: 22685174

Dev A*, Fang J*, Sathyanarayana P, Pradeep A, Emerson C, Wojchowski DM. During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool. (2010). Blood, 116: 5334-46. (*co-first author). PMID: 20810925

Fang J, Menon M, Zhang D, Torbett B, Oxburgh L, Tschan M, Houde E, Wojchowski DM. Attenuation of EPO-dependent erythroblast formation by death-associated protein kinase-2. (2008). Blood, 112: 886-90. PMID: 18535204

Fang J, Menon M, Kapelle W, Bogacheva O, Bogachev O, Houde E, Browne S, Sathyanarayana P, Wojchowski DM. EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts. (2007). Blood, 110: 2361-70. PMID: 17548578

Shen ZX*, Shi ZZ*, Fang J*, Gu BW, Li JM, Zhu YM, Shi JY, Zheng PZ, Yan H, Liu YF, Chen Y, Shen Y, Wu W, Tang W, Waxman S, De Thé H, Wang ZY, Chen SJ, Chen Z. All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. (2004). Proc Natl Acad Sci U S A, 101: 5328-35. (*co-first author). PMID: 15044693

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