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Department of Chemistry and Biochemistry


Makris Lab

Biochemistry and Molecular Biology

The research interests of these faculty encompass all areas of biochemistry, including cell and molecular biology, enzymology, spectroscopy, protein crystallography, and bio-inorganic chemistry.

 

chruszcz

Maksmilian Chruszcz

"We focus on the structural analysis of food and inhaled allergens to determine the molecular basis of allergic diseases.  Moreover, we study proteins that are potential targets for the development of antibiotics and pesticides."

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Parastoo Hashemi

"Development of electrochemical microelectrode methodology for real-time quantitate analysis of biologically and environmentally important molecules. Neurotransmitter roles in depression and neurodegeneration. Real-time trace metal speciation studies."

kathikeyan

Mythreye Karthikeyan

"We focus on defining the mechanisms by which growth factors transduce their signals in cells to alter cellular behavior using a combination of biochemical, cell signaling, and cell biological approaches.  Our goal is to identify mechanisms that may serve as therapeutic targets for the treatment of human disease."

thomas makris

Thomas Makris

"We are developing methods to leverage enzyme catalysts for the production of novel therapeutics and sustainable fuels."

c. outten

Caryn Outten

"The C. Outten research group is focused on two interconnected projects: (1) identifying the mechanisms for maintaining adequate intracellular levels of the essential metal iron, and (2) characterizing intracellular factors that control mitochondrial thiol redox balance.  We take a multidisciplinary approach to tackle these projects, combining bioinorganic, biochemical, genetic, and molecular and cell biology techniques."

w. outten

Wayne Outten

"We study the homeostasis and metabolism of essential metals like copper, iron and zinc, with the goals of disrupting metal metabolism in bacteria during infection and correcting defects in human metal metabolism that lead to disease."

sodetz

James Sodetz

"Our focus is on understanding how human serum complement proteins C5b, C6, C7, C8 and C9 assemble to form a lethal, pore-like 'membrane attack complex' (MAC) on the membrane of infectious organisms."

hui wang

Hui Wang

"We use state-of-the-art single-molecule spectroscopic techniques to resolve the conformational dynamics of complicated biomolecules."

q. wang

Qian Wang

"The overall research objective of Dr. Qian Wang's laboratory focuses on using chemical biology tools to probe intracellular activities and the development of hierarchically-structured nanomaterials to study the cooperative response of cells to extracellular matrixes."