Global Carolina develops initiatives with other institutions around the world, facilitates international collaboration and exchange agreements, and supports the international activities of colleges and departments across campus. The following offices are part of the Global Carolina Initiative:

• The Education Abroad Office, which advises students about international study, while promoting, developing and administering the university's study abroad and student exchange programs.
• International Student and Scholar Support, which provides guidance and assistance to international students at the university and manages immigration regulatory affairs related to students.
• The International Accelerator Program, which eases the transition for international students from high school in their home country to the University of South Carolina by combining credit-bearing courses from their first year of their degree with additional academic support, instruction and cultural experiences.
• English Programs for Internationals, which provides superior ESL instruction and personalized services accredited by the Commission on English Language Program Accreditation (CEA).