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School of Medicine Greenville

Faculty Profile

Faculty and Staff

Mark A. O'Rourke, M.D.

Title: Adjunct Associate Professor
Medicine  
School of Medicine Greenville
E-mail: mark.orourke@prismahealth.org
   
Office: 701 Grove Road
Greenville SC 29605
profile

Bio

Background: Dr. O’Rourke is a medical oncology cancer specialist with the GHS Cancer Institute. He grew up in Santa Barbara, California and completed his undergraduate studies at Stanford University. He served in the U.S. Navy as an instructor at the Naval Nuclear Power School. He completed medical school at UCLA and residency training at the Duke University Medical Center, where he went on to complete fellowships in medical oncology and geriatrics. He has been a member of the medical staff at GHS since 1990.

Dr. O’Rourke is a medical oncology cancer specialist with the Prisma Health Upstate Cancer Institute. He grew up in Santa Barbara, California and completed his undergraduate studies at Stanford University. He served in the U.S. Navy as an instructor at the Naval Nuclear Power School. He completed medical school at UCLA and residency training at the Duke University Medical Center, where he went on to complete fellowships in medical oncology and geriatrics. He has been a member of the medical staff at Greenville Health System, now Prisma Health, since 1990.

Dr. O’Rourke’s practice is blood and cancer illnesses that affect adults. He cares for people living with the full spectrum of cancers. He also participates in the Prisma Gastrointestinal Cancer Multidisciplinary Clinic, in which a multi-specialty team of physicians and nurses provide specialty evaluation and care for cancers of the stomach, pancreas, bile ducts, liver, colon and rectum. He serves on the SWOG Cancer Research Network Gastrointestinal Cancer Committee and participates in the development and conduct of national and international research in gastrointestinal cancer.

Dr. O’Rourke is active in cancer clinical research and offers participation in National Cancer Institute (NCI) clinical trials in the NCI Community Oncology Research Program (NCORP) at the Prisma Health Upstate Cancer Institute. He is also an investigator in the Institute for Translation Oncology (ITOR) clinical trials at the GHS Cancer Institute, where precision medicine, new drugs and immunotherapy are developed. At a national level, he is an active investigator in the NCI research base, called the SWOG Cancer Research Network, where he is a founding co-chair of the Palliative and End-of-Life Care Committee. He also serves on the NCI Steering committee which reviews and recommends research studies that address Symptom Control and Quality of Life.

Dr. O’Rourke is a national expert in the newly evolving field of cancer survivorship care, devoted to helping cancer survivors regain their full physical, mental, emotional, and spiritual health after cancer treatment. He is also a practitioner of integrative oncology, which addresses the full range of a person’s experience with cancer, including exercise, nutrition, sleep, mind-body therapies, social support, and mental and spiritual health. His teams’ research at Prisma has shown benefits for cancer survivors of acupuncture, mindfulness meditation and heart rate variability (HRV) biofeedback.

Dr. O’Rourke has a particular interest in medical ethics and has served on the ethics committees of the South Carolina Medical Association (SCMA) and the American Society of Clinical Oncology. He has taken additional training and become board certified in palliative care medicine, which is a new specialty that addresses symptom control, pain relief, communication, and coordination of care for seriously ill persons. He worked with the SCMA to improve physician/patient communication, which led to legislation creating the South Carolina Physician Orders for Scope of Treatment (POST) in 2019.

Dr. O’Rourke is a clinical assistant professor at the University of South Carolina, Clemson University and the UofSC School of Medicine Grenville and has been teaching medical students and physicians in training for over three decades. In June 2020, Dr. O’Rourke received the UofSC School of Medicine Greenville’s Outstanding Service Award. The award “recognizes individuals for their meaningful service contributions to the advancement of their professions, the mission of the medical school and the communities we serve.”

Dr. O’Rourke and his wife, Rita, have two children, three grandchildren, and a labradoodle. In his free time, he helps Rita in the garden and in the kitchen.
Teaching Interest(s): Areas of Focus
Blood and cancer illnesses that affect adults
Gastrointestinal cancers
Integrative oncology and mind-body therapies
National Cancer Institute (NCI) clinical trials in the NCI Community Oncology Research Program (NCORP)
Institute for Translation Oncology (ITOR) clinical trials of new cancer drugs and immunotherapy
Palliative Care and Quality of Life cancer research
Cancer care delivery research
Research Interest(s): Integrative oncology and mind-body therapies
National Cancer Institute (NCI) clinical trials in the NCI Community Oncology Research Program (NCORP)
Institute for Translation Oncology (ITOR) clinical trials of new cancer drugs and immunotherapy
Palliative Care and Quality of Life cancer research
Cancer care delivery research
Honors & Awards: Outstanding Service Award
Outstanding Contributions Certificate
Physician of the Year Award for Community Service
Order of St. Luke Award
Golden Apple Award
Professional Affiliations: Co-chair, SWOG Cancer Research Network Palliative and End of Life Care Committee
Other -
National Cancer Institute Symptom Management & Health-Related Quality of Life Steering Committee (SxQOL SC)
Member
Coalition for the Care of the Seriously Ill
Other - Member of the Steering Committee
American Academy of Hospice and Palliative Medicine
Member
Catholic Medical Association
Member
South Carolina Cancer Alliance
Other - Founding Member
Christian Medical Association
Member
South Carolina Pain Initiative
Member
South Carolina Oncology Society
Member
Greenville County Medical Society
Member
South Carolina Medical Association
Member
Southwest Oncology Group, now SWOG Cancer Research Network (National Cancer Institute)
Member
American Medical Association
Member
American Society for Clinical Oncology
Member
ASCO Survivorship Commitee
Member
SWOG Digital Engagement Committee
Member
South Carolina Governor's Prescription Drug Abuse Prevention Council
Member
ASCO Ethics Commitee
Member
SCMA Bioethics Committee
Member
Hospice House of Greenville Board
Other - Chair of the Board
South Carolina Department of Health & Human Services Pharmacy & Therapeutics Committee
Member
Legislative representative, Greenville County Medical Society
Other - Legislative Representative
Secretary/Treasurer, Greenville County Medical Society
Other - Secretary / Treasurer
South Carolina Cancer Alliance, Policy and Advocacy Task Force
Other - Vice Chairman
South Carolina Department of Health and Environmental Control Cancer Control Advisory Committee
Member
Bon Secours St. Francis Health System Foundation
Member
Hospice of the Foothills Foundation Board
Member
South Carolina Medicare Part B Carrier Advisory Committee
Other - Vice Chairman
Insights, Greenville Chapter, South Carolina Citizens for Life, Community Advisory Board
Other - Chairman
SCMA Interdisciplinary Council
Other - Oncology Representative
South Carolina Oncology Society
Other - Secretary
Upstate SC Chapter Board, Alzheimer's Association
Member
Bioethics Resource Group
Member
Nursing Home Ethics Group Subcommittee
Member

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