RFA-AI-27-004:Atopic Dermatitis Research Network (ADRN) (U19 Clinical Trial Optional)

Sponsor: DHHS, NIH
Internal Deadline: 07/17/2026
Institutional Submission Limit: 1
Sponsor Deadline: 09/24/2026
Program Website

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for the Atopic Dermatitis Research Network (ADRN) program. The ADRN program will support Centers that integrate clinical and translational research to improve our understanding and management of atopic dermatitis with emphasis on chronic skin inflammation and the defense mechanisms of the skin.

To assist public and private nonprofit institutions and individuals to establish, expand and improve biomedical research and research training in infectious diseases and related areas; to conduct developmental research, to produce and test research materials. To assist public, private and commercial institutions to conduct developmental research, to produce and test research materials, to provide research services as required by the agency for programs in infectious diseases, and controlling disease caused by infectious or parasitic agents, allergic and immunologic diseases and related areas. Projects range from studies of microbial physiology and antigenic structure to collaborative trials of experimental drugs and vaccines, mechanisms of resistance to antibiotics as well as research dealing with epidemiological observations in hospitalized patients or community populations and progress in allergic and immunologic diseases. Because of this dual focus, the program encompasses both basic research and clinical research. 

ADRN Research Center Structure

Each ADRN Center application will support Research Projects and Cores, as described in Section IV. The allocation of funds to each component is at the discretion of the investigator, but the greatest emphasis should be placed on the Research Projects. The research proposed by an ADRN Center should be highly integrated and synergistic. This may be achieved within single institutions or by multi-institutional applications for research areas of interest to this NOFO.

• Administrative Core - Responsible for the overall management, communication, coordination, and supervision of the Center. The Administrative Core Lead will provide leadership and guidance in fulfilling the stated objectives of the Center and is responsible for generating an infrastructure that promotes cross-discipline interactions among all Cores and Research Projects. One ADRN Center recipient will be selected by National Institute of Allergy and Infectious Diseases (NIAID), to


• manage the Infrastructure and Opportunity Fund (IOF) and Systems Biology of Early Atopy (SUNBEAM) participation funds for the entire ADRN program.


• Data Stewardship Core – Will provide central data management and analysis services (e.g., database establishment, data collection and cleaning, data integration, data storage) to other Core(s) and Research Projects within the individual ADRN Center.


• Clinical Core - As necessary, a single Clinical Core will be responsible for the recruitment, organizational, and regulatory aspects of a clinical trial or any proposed observational clinical study, including tracking samples collected as part of the clinical trial or observational study.


• Scientific Core(s) - As necessary, the Core(s) will ensure the success of the supported Research Projects and the overall goal(s) of the ADRN Center. Examples of possible Scientific Cores include, but are not limited to, a Genetics/Genomics Core, a Flow Cytometry Core, a Microbiome Core, and/or other Research Laboratory Cores.


• Research Projects - Research Projects organized around a common theme or hypothesis that contribute to the Center's goals and objectives. As appropriate, the Research Project(s) may support a single-site pilot clinical trial or an observational study involving individuals, or samples from individuals with AD as part of or as an entire Research Project offering insight into disease mechanisms or therapeutic response.

Steering Committee - PD(s)/PI(s) funded under this program will become members of the ADRN Steering Committee after award that serves as the main governing body for the network. ADRN PD(s)/PI(s) will become members of the SUNBEAM Steering Group after award to contribute AD expertise to the SUNBEAM study.

Only one application per institution (normally identified by having a unique entity identifier (UEI) number or NIH IPF number) is allowed.

Submission Process

Limited submissions MUST be coordinated with the Office of the Vice President for Research.

If interested in applying for this opportunity, please combine the following items into a single PDF and email to resdev@mailbox.sc.edu by 5pm on the INTERNAL DEADLINE above:

• Cover page with grant program name & number (if applicable) to which you are applying, your project title, PI (name, department/unit, & email), and list of co-PIs/key collaborators (name & department/unit)
• a two-page project abstract addressing key components/criteria for this specific grant program
• a 2-3 page CV/biosketch for the PI (SCiENcv preferred)