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Coronavirus: Get complete details about the university's response to COVID-19.

College of Pharmacy

  • S.C. State House

South Carolina COVID-19 Treatment Outcomes Registry

The South Carolina COVID-19 Treatment Outcomes Registry will provide critical data to assess short- and long-term safety and effectiveness outcomes among hospitalized patients for clinicians, regulatory agencies, and scholars.

Ready to Participate?
Please complete and submit the Facility Intake / Interest Form.

 

Overview

Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread from person to person. The virus that causes COVID-19 is a novel coronavirus that was first identified during an investigation into an outbreak in Wuhan, China. Since that time, the World Health Organization has declared a global pandemic with confirmed COVID-19 cases in the millions.

The S.C. Department of Health and Environmental Control is working closely with federal, state, local partners to respond to this ongoing public health event. South Carolinians may be at particularly high risk for COVID-19 due to significant risk factors such as obesity, underlying cardiovascular disease and diabetes mellitus.

Current pharmacologic treatments for COVID-19 are considered experimental and there is significant need for safety and effectiveness data. The S.C. COVID-19 Treatment Outcomes Registry will provide access to that invaluable data for clinicians, regulatory agencies, and scholars across the state.

Brandon Bookstaver portrait

Primary Investigator

P. Brandon Bookstaver, Pharm.D.
Associate Professor & Director of Residency and Fellowship Training
University of South Carolina College of Pharmacy

Sharon Weissman portrait

Co-Primary Investigator

Sharon Weissman, M.D. 
Professor of Clinical Internal Medicine 
University of South Carolina School of Medicine 
Chief of Division of Infectious Diseases
Prisma Health/University of South Carolina Medical Group

Co-Investigators

Divya Ahuja, M.D. 
Department of Medicine, Division of Infectious Diseases
University of South Carolina School of Medicine
Prisma Health USC Medical Group

Majdi Al-Hasan, M.D.
Department of Medicine, Division of Infectious Diseases
University of South Carolina School of Medicine
Prisma Health USC Medical Group

Ramesh Bharadwaj, M.D.
Infectious Disease Outpatient Clinic
McLeod Health

Edwin Hayes, M.D. 
Department of Medicine, Division of Infectious Diseases
University of South Carolina School of Medicine
Prisma Health USC Medical Group

Julie A. Justo, Pharm.D., M.S.
Department of Clinical Pharmacy & Outcomes Sciences,
University of South Carolina College of Pharmacy

Akin Olatosi, M.D.
HopeHealth

John Schrank, Jr., M.D.
Division of Infectious Diseases, Prisma Health Upstate

Jenna Swindler, Pharm.D.
McLeod Health

Aim 1: Create a statewide registry of hospitalized, COVID-19 infected patients admitted to inpatient facilities in South Carolina

Aim 2: Determine COVID-19 treatment patterns among South Carolina hospitals

Aim 3: Assess short term safety and effectiveness outcomes among the pharmacologic treatment approaches

Aim 4: Assess long term safety and effectiveness outcomes in patients post-discharge

Inclusion Criteria 

  • COVID-19 positive by polymerase chain reaction (PCR) or equivalent, approved testing method
  • Hospitalized in an inpatient facility in South Carolina
  • Survived at least 24 hours following admission
  • Patients who received at least 1 dose of a pharmacologic therapy intended to treat SARS CoV 2 virus will be evaluated for drug-related adverse event outcomes as discussed below.

Potential treatments include: hydroxychloroquine, chloroquine, tocilizumab, remdesivir, lopinavir/ritonavir, ribavirin, convalescent serum and adjunctive zinc, Vitamin C or azithromycin. Because possible treatments are under investigation, this list is not considered exhaustive.

Exclusion Criteria: 

  • Patient expired in the initial 24 hours since initial hospital admission (adjusted for facility transfers)
  • Pertinent data for registry incomplete due to patient transfer between facilities or limited documentation in electronic health record
SC DHEC

MUSC Health

McLeod Health
SCSHP Prisma Health ASC-SC
 
 South Carolina Center for Rural and Primary Healthcare
 
 
South Carolina Infectious Diseases Society
 
 
 

This work was supported by the Office of the Vice President for Research at the University of South Carolina . 

 


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