General Research Interests
Research on cardiovascular diseases is primarily pursued by faculty members in the Department of Cell Biology and Anatomy. They are actively involved in research that focuses on:
- Molecular, structural and hormonal basis of cardiac and vascular development
- Injury and repair following stress
- Remodeling and associated changes
Our Researchers
| Researchers | Research Focus | Keywords (hidden column) |
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Extracellular matrix(fibroblast) behavior and gene expression in cardiovascular disease. |
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Molecular and cellular mechanism that links obesity, diabetes and vascular disease, with a specific focus on the role of ubiquitin-proteasome system (Keap1-mediated Nrf2 ubiquitination and deubiquitinating enzymes, UCH-L1- or CYLD) in the maintenance of vascular homeostasis. |
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Role of macrophage Apolipoprotein E (ApoE), oxidized LDL (oxLDL), toll-like receptors (TLRs) and microRNA (miRNA155) in regression of atherosclerotic plaques |
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Extracellular matrix, collagen, its receptor (DDR1 and DDR2) and gold nanoparticles in collagen remodeling and cardiac development. |
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Rich Goodwin, Ph.D. |
Mechanisms of embryology, in vitro tissue regeneration, coronary vascular and cardiac regeneration. |
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Mechanical properties of mouse atherosclerotic lesions and to develop mathematical models to describe their biomechanical behavior before and after drug treatment. |
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Immunotherapy for Cardiovascular disorders; vascular leak syndrome |
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Role of immune cells in vasculitis |
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Molecular regulation of vascular endothelial and smooth muscle cells. |
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Congenital cardiac malformations- Development of atrioventricular (AV) canal – AV valves and interventicular septum |
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Molecular and cell biology instrumentation for in vitro, in vivo and whole body imaging studies of embryonic, fetal, neonatal and adult animals. Primary interests involve the roles of growth factors and mechanical forces on the development and function of myofibrils in cardiac myocytes. |
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Etiology of congenital heart defects — emphasis on role of cardiac laterality genes in overall heart morphogenesis. |
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Diabetes and Cardiovascular disease |
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Community Health Care Advocacy and Cardiovascular Diseases |