Transgenic and surgical animal models provide insight into the type and extent of vascular abnormalities otherwise not measurable in human models. In these collaborative research project we explored blood vessel histomechanics from knockout and heterozygous mouse models of connective tissue disorders (i.e., Fibrillin1mgR/mgR, Fibullin5-/-), and smooth muscle dysfunction (i.e., mdx, Sgcd-/-, acta2-/-), and atherosclerosis (ApoE-/-) as well as surgical models of hypertension. All studies identified the current stress-state and microstructure of the diseased tissue and found dramatic differences indicative of adaptive and maladaptive remodeling. All results were fit to biaxial nonlinear mechanical models enabling translation of the findings to other interested researchers.
- Eberth JF, Taucer AI, Wilson E, Humphrey JD. Altered biaxial mechanical behavior of carotid arteries in fibrillin-1 deficient mice. Annals of Biomedical Engineering. Jun. 2009, 37(6): pp. 1093-1104. (related figure above)
- Bersi M, Feruzzi J, Eberth JF, Gleason RL, Humphrey JD. Consistent Biomechanical Phenotyping of Common Carotid Arteries From Eight Genetic, Pharmacological, and Surgical Mouse Models. Annals of Biomedical Engineering. Jun. (2014) 42(6), pp. 1207-1223.
- Watson SR, Piaomu L, Peńa EA, Sutton MA, Eberth JF, Lessner SM. Diet-Induced Vascular Remodeling Produces a Shift in Collagen Fiber Angle Distribution in a Mouse Model of Atherosclerosis. The FASEB Journal. Apr. 2015, 29(S1).