Magnetic nanoparticles, particularly superparamagnetic ferrite nanoparticles coated with bio-functional materials/biocompatible polymers with a diameter of 6 ~ 15 nm mean particle size have been and are being paid a considerable attention in nanomedicine, regenerative medicine, thermal nanomedicine, and nano-theranostics, because they have attractive physical, biotechnical, and physiological properties for a variety of clinical applications and treatments: (1) they are chemically stable and are expected to have higher biocompatibility, (2) they can be transported to the targeted cells by blood circulation or an external magnetic field (action in distance property), (3) they can be self-heated under an AC magnetic field, and (4) they can be used for imaging contrast agents by externally applied magnetic field.
Our first research goal is to develop new ferrite superparamagnetic nanoparticles/nanofluids, which can overcome the critical challenges of magnetic nanoparticles/nanofluids currently facing in various real clinics. The second is to develop new clinical treatment and diagnostic modalities using the developed nanoparticles/nanofluids and advanced electronics/spintronics (magnetics) high-performance bioinstrumentation technology. Our research efforts in this research area include the development of: 1) local magnetic nanofluid hyperthermia systems for treating various tumors (prostate/breast cancer, glioblastoma multiforme), 2) new thermal nanomedicine modality for ocular neuroprotection in glaucoma based on local induction of heat shock proteins, 3) a new type of magnetic antenna designed by magnetic nanoparticles/nanofluids for AC electromagnetic field stimulation and Deep or Repetitive TMS (Transcranial Magnetic Stimulation) for treating neurodegenerative diseases such as Parkinson’s disease, epilepsy, and dystonia etc., 4) heat triggered drug delivery system for medications, 5) ultra-high r2-relaxivity of MRI nanofluid agents for single molecular imaging and single cell level cancer diagnosis, 6) a new “Hemostasis modality” based on magnetic nanofluid hyperthermia for efficaciously stopping bone bleeding and curing TBI (Traumatic Brain Injury), and 7) remote control of "neuron signal transmission", and Ca2+ ion open channel physiological properties by AC magnetically-induced thermal stimulation for neuronal engineering and osteoporosis.
Magnetic nanoparticles (MNPs) can convert AC electromagnetic energy into thermal energy in a non-invasive manner. MNPs injected into the tumor area increase the local temperature and kill the cancer cells. However, this strategy suffers from a low heat inducing capability of MNPs. We developed new types of MNPs to solve this problem by redesigning of MNPs at an atomic level. Our newly developed magnetically softened iron oxide MNPs can induce immense thermal energy (intrinsic loss power (ILP): 14 nH m2 kg−1) in the cancer cells to completely destroy them. In particular, newly developed nanoparticle is operated under a physiologically bio-safe range of AC magnetic field which is our unique technology and is not harmful to patients.
- Jang, J.-t., Lee, J., Seon, J., Ju, E., Kim, M., Kim, Y.I., Kim, M.G., Takemura, Y., Arbab, A.S., Kang, K.W., Park, K.H., Paek, S.H., Bae, S."Giant Magnetic Heat Induction of Magnesium-Doped γ-Fe2O3 Superparamagnetic nanoparticles for Completely Killing Tumors" Mater. 2018, 30, 1704362
- Jang, J.-t., Bae, S. "Mg shallow doping effects on the ac magnetic self-heating characteristics of γ-Fe2O3 superparamagnetic nanoparticles for highly efficient hyperthermia" Phys. Lett. 2017, 111, 183703
- Jang, J.-t., Jeoung, J.W., Park, J.H. Lee, W.J., Kim, Y.J., Seon, J., Kim, M., Lee, J., Peak, S.H., Park, K.H., Bae, S."Effects of Recovery Time during Magnetic Nanofluid Hyperthermia on the Induction Behavior and Efficiency of Heat Shock Proteins 72" Scientific Reports, 2017, 7, 13942