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Faculty and Staff

Lukasz Szatkowski

Title: Assistant Professor of Chemistry
Department: Division of Science, Mathematics, and Engineering
USC Sumter
Email: LUKASZ@mailbox.sc.edu
Phone: 803-938-3716
Office: Science 113
Resources: Research Gate 
Google Scholar
Image of Lukasz Szatkowski
Teaches: 

General Chemistry (CHEM111, CHEM111L, CHEM112, CHEM112L) and Organic Chemistry (CHEM333, CHEM333L, CHEM334, CHEM334L)

 Education:

Oct 2007 - Sep 2012 

Lodz University of Technology, Faculty of Chemistry, 

Doctor of Philosophy in field of Chemistry 

Major: Physical and Computational Chemistry 

Supervisor: Professor Piotr Paneth; Co-supervisor: Agnieszka Dybała-Defratyka, PhD 

PhD Thesis title: Mechanisms of enzymatic dehalogenation of chlorophenols derivatives 

Sep 2002 - Jun 2007 

Lodz University of Technology, Faculty of Chemistry 

Master of Science in field of Chemistry 

Major: Computational Chemistry and Molecular Modeling 

Supervisor: Professor Piotr Paneth 

Master’s Thesis title: Modeling properties of Pt (II), Pd (II) and Cu (II) complex compounds 

Invited book chapters: 1. Szatkowski, L., Manna, R., M., Grzybkowska, A., Kamiński, R., Dybala-Defratyka, A., Paneth, P., Measurement and Prediction of Chlorine Kinetic Isotope Effects in Enzymatic Systems, in Harris, M., Anderson, V., (Eds.) “Measurement and Analysis of Kinetic Isotope Effects, Methods in Enzymology", Volume 596, 2017, 179, DOI: 10.1016/bs.mie.2017.07.021 

Publications: 1. Szatkowski, L., Merz, D. R., Jiang, N., Ejikeme, I., Belonogov, L., Ross, J. L., Dima., R. I., “The Mechanics of the Microtubule Seam Interface Probed by Molecular Simulations and In Vitro Severing Experiments”, Journal of Physical Chemistry B, 2019, 123, 4888-4900, DOI: 10.1021/acs.jpcb.9b03059 

2. Szatkowski, L., Lynn, M., Williams, M., Baldo, A., Tardiff, J., Schwartz, S. D., “Proof of principle that molecular modeling followed by a biophysical experiment can develop small molecules that restore function to the cardiac thin filament in the presence of cardiomyopathic mutations”, ACS Omega, 2019, 4, 6492-6501, DOI: 10.1021/acsomega.8b03340 

3. Szatkowski, L., Merz, D. R., Ross, J. L., Dima., R. I. “Mechanical Stability of Microtubule Lattices - Molecular Dynamic Indentation Studies”, Biophysical Journal, 2019, Supplement 1 to 116, 257A; DOI: 10.1016/j.bpj.2018.11.1401 

4. Szatkowski L., Hall M. B., Molybdenum Trihydride Complexes: A Computational Model of H2 Elimination Reaction From 17-electrons Molybdenum Complexes, Inorg. Chem., 2017, 56 (16), 9653, DOI: 10.1021/acs.inorgchem.6b02805 

5. Szatkowski L., Hall M. B., Dehalogenation of chloroalkanes by nickel(I) porphyrin derivatives, a computational study, Dalton Trans., 2016, 45, 16869-16877, DOI: 10.1039/C6DT02632J 

6. Szatkowski L., Hall M. B., Molybdenum Trihydride Complexes: Computational Determinations of Hydrogen Positions and Rearrangement Mechanisms, Inorg. Chem., 2015, 54 (13), 6380, DOI: 10.1021/acs.inorgchem.5b00693 

7. Szatkowski L, Dybala-Defratyka A., Reply to comment on “A computational study on enzymatically driven oxidative coupling of chlorophenols: An indirect dehalogenation reaction [Szatkowski and Dybala-Defratyka, Chemosphere 91 (2013) 258–264]”, Chemosphere, 2013, 93(9), 2204, DOI: 10.1016/j.chemosphere.2013.04.051 

8. Szatkowski L, Dybala-Defratyka A., Batarseh C., Blum J., Haliczc L., Gelman F., Bromine kinetic isotope effects: insight into Grignard reagent formation, New J. Chem., 2013, 37, 2241, DOI: 10.1039/c3nj00197k 

9. Szatkowski L, Dybala-Defratyka A., A computational study on enzymatically driven oxidative coupling of chlorophenols: An indirect dehalogenation reaction, Chemosphere, 2013, 91(3), 258, DOI: 10.1016/j.chemosphere.2012.11.022 

10. Szatkowski, L., Thompson, M. K., Kaminski, R., Franzen, S., Dybala-Defratyka, A., Oxidative dechlorination of halogenated phenols catalyzed by two distinct enzymes: Horseradish peroxidase and dehaloperoxidase, Arch. Biochem. Biophys., 2011, 505(1),22, DOI: 10.1016/j.abb.2010.09.018 

11. Budzisz, E. Lorenz, I.-P., Mayer, P., Paneth, P., Szatkowski, Krajewska, U., Rozalski, M., Miernicka, M., Synthesis, crystal structure, theoretical calculation and cytotoxic effect of new Pt(II), Pd(II) and Cu(II) complexes with pyridine-pyrazoles derivatives, New J. Chem., 2008, 32, 2238, DOI: 10.1039/B808301K 

12. Dybala-Defratyka, A. Szatkowski, L., Kaminski, R., Wujec, M., Siwek, A., Paneth, P., Kinetic Isotope Effects on Dehalogenations at an Aromatic Carbon, Environ. Sci. Technol., 2008, 42 (21), 7744, DOI: 10.1021/es800276y 

13. Dzierzawska, J., Jarota, A., Karolak, M., Piotrowski, L., Placek, I., Swiderek, K., Szatkowski, L., Paneth, P., Carbon and secondary deuterium kinetic isotope effects on SN2 methyl transfer reactions, J. Phys. Org. Chem., 2007, 20 (12), 1114, DOI: 10.1002/poc.1267 

14. Papajak, E., Kwiecień, R. A., Rudziński, J., Sicińska, D., Kamiński, R., Szatkowski, L., Kurihara, T., Esaki, N., Paneth, P., Mechanism of the Reaction Catalyzed by dl-2-Haloacid Dehalogenase As Determined from Kinetic Isotope Effects, Biochem., 2006, 45 (19), 6012, DOI: 10.1021/bi0519553 

Research Grants/Fellowships:

Oct 2010 - Mar 2012 

Ministry of Science and Higher Education, Poland, Ph.D. grant, 

Lodz University of Technology 

Title: THE MECHANISM OF DEHALOGENATION OF CHLOROPHENOLS CATALYZED BY HORSERADISH PEROXIDASE, 

Main participant 

Oct 2007- Jun 2009 

Ministry of Science and Higher Education, Poland, 

Lodz University of Technology, 

Title: STUDY ON ENZYMATIC DEGRADATION OF HALOGENATED PHENOLS WITH THE USE OF CHLORINE ISOTOPE EFFECTS AND MOLECULAR MODELING, 

Participant 

2009 

“Scholarship to support innovative research of doctoral students” co-financed by European Social Fund and the National Budget 

Title: MEASUREMENTS OF CHLORINE ISOTOPIC COMPOSITION IN SAMPLES FROM CHLORINATED AROMATIC COMPOUND. CHLORINE KINETIC ISOTOPE EFFECT IN REACTIONS CATALYZED BY HRP AND DHP 

Main participant 

Honors and Awards:

2009 

Ministry of Health, Poland, award for series of publication 

Memberships and Affiliations:

Oct 2019 - present 

American Physical Society 

Jan 2017 - present 

Biophysical Society 

Mar 2014 - present 

American Chemical Society 

Mar 2003 - Sep 2006 

Membership in The Faculty Student Council, Faculty of Chemistry, Lodz University of Technology 

Mar 2003 - Sep 2006 

Membership in the Faculty Council, Faculty of Chemistry, Lodz University of Technology 

Sep 2011 - Jun 2013 

Member of ISOTOPE 2013 Conference Organizing Committee 

Invited Presentations:

2019 

Technical University of Lodz, Lodz, Poland 

University of Warsaw, Warsaw, Poland

Presentations:

2020

APS National Meeting, Denver, CO, United States – Oral presentation

Title: MECHANICAL STABILITY OF MICROTUBULE LATTICES UNDER HIGH CROWDEDNESS

2019

63rd Biophysical Society Annual Meeting, Baltimore, MD, United States – Poster presentation

Title: MECHANICAL STABILITY OF MICROTUBULE LATTICES - MOLECULAR DYNAMIC INDENTATION STUDIES

2017

61st Biophysical Society Annual Meeting, New Orleans, LA, United States – Poster presentation

Title: A NEW PARADIGM USING COMPUTATION AND EXPERIMENT TO DESIGN AND TEST DRUGS TO TREAT CARDIOMYOPATHIES

2015

Gordon Research Conference Inorganic Reaction Mechanisms, Hotel Galvez, Galveston, TX, United States – Poster presentation

Title: DIHYDRIDE VS. DIHYDROGEN THE INFLUENCE OF LIGANDS ON THE ORIENTATION OF HYDROGENS IN THE OSMIUM COMPLEX COMPOUNDS

2014

Gordon Research Conference Isotopes in Biological & Chemical Sciences, Hotel Galvez, Galveston, TX, United States – Oral presentation

Title: CHLOROMETHANE DEHALOGENATION BY ISOBACTERIOCHLORIN TRANSITION METAL COMPLEXES

Gordon Research Conference Isotopes in Biological & Chemical Sciences, Hotel Galvez, Galveston, TX, United States – Poster presentation

Title: IN SEARCH OF HYDROGENS - A COMPUTATIONAL STUDY OF REACTIVITY OF MOLYBDENUM TRIHYDRIDE COMPLEXES

2013

ISOTOPES 2013, Sopot, Poland – Oral presentation

Title: MOLYBDENUM TRIHYDRIDE COMPLEXES - OXIDATIVELY INDUCED REDUCTION ELIMINATION

ACS SouthWest Regional Meeting, Waco, TX, United States – Poster presentation

Title: MOLYBDENUM TRIHYDRIDE COMPLEXES - OXIDATIVELY INDUCED REDUCTION ELIMINATION

2012

Gordon Research Seminars Isotopes in Biological & Chemical Sciences, Hotel Galvez, Galveston, TX, United States – Poster presentation

Title: TO POLYMERIZE OR TO DEHALOGENATE? A STUDY MECHANISM OF DEGRADATION OF CHLOROPHENOLS CATALYZED BY PEROXIDASES

Gordon Research Conference Isotopes in Biological & Chemical Sciences, Hotel Galvez, Galveston, TX, United States – Poster presentation

Title: TO POLYMERIZE OR TO DEHALOGENATE? A STUDY MECHANISM OF DEGRADATION OF CHLOROPHENOLS CATALYZED BY PEROXIDASES

IARC Workshop on Reactive Intermediates for Young Scholars and Graduate Students, Hotel Moscicki, Spala, Poland – Oral presentation

Title: TO POLYMERIZE OR TO DEHALOGENATE? A STUDY MECHANISM OF DEGRADATION OF CHLOROPHENOLS CATALYZED BY PEROXIDASES

2011

ISOTOPES 2011, Château Laval, Gréoux-les-Bains, Provence-Alpes-Côte d’Azur, FRANCE – Poster presentation

Title: TO POLYMERIZE OR TO DEHALOGENATE? A COMPUTATIONAL STUDY ON OXIDATIVE COUPLING OF CHLOROPHENOLS

2009

ISOTOPES 2009, Cluj - Napoca, ROMANIA – Poster presentation

Title: CHLORINE KINETIC ISOTOPE EFFECT IN REACTIONS CATALYZED BY HRP& DHP

2008

XII MICROSYMPOSIUM – Kinetic Methods of study reactions mechanisms in solutions, Adam Mickiewicz University, Faculty of Chemistry, Poznan, POLAND – Poster presentation

Title: KINETIC ISOTOPE EFFECTS OF ATRAZINE HYDROLYSIS

 

 


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