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Environmental Health and Safety


Select Agents and Biosafety Level 3 Research

Select Agent Regulations

The Federal Select Agent Program oversees the possession, use and transfer of biological select agents and toxins, which have the potential to pose a severe threat to public, animal or plant health or to animal or plant products.  The Federal Select Agent Program is jointly comprised of two regulatory oversight agencies:

  • Centers for Disease Control and Prevention/Division of Select Agents and Toxins
  • Animal and Plant Health Inspection Service/Agriculture Select Agent Services
     

Requirements for Select Agents & Biosafety Level 3 Research

Research involving select agents and research conducted at biosafety level 3 (BSL-3) containment requires additional training, enhanced medical surveillance plans, complex facility maintenance and operations, and other specialized biosafety, security, and incident response plans. A research summary must be submitted to the Institutional Biosafety Committee (IBC) Chair and USC’s Biological Safety Officer prior to any faculty member submitting a grant for this type of research, or any department hiring a new faculty member to conduct select agent or BSL-3 research. This notification must be made with sufficient advanced notice for EHS and the IBC to complete a risk assessment for the proposed research, and to evaluate the resources necessary for the EHS Biosafety Office to provide adequate safety and compliance oversight. All research involving select agents or BSL-3 containment that is conducted at or sponsored by the university must be reviewed and approved by the IBC prior to initiating research.

Select Agents & Toxins Resources


CDC/USDA Federal Select Agent Program

Select Agent Regulations

Select Agents and Toxins List

Select Agents and Toxins Exclusions

Permissible Biological Toxin Amounts

Due Diligence Provision for Transferring Biological Toxins

USC Biological Toxins Inventory Form [pdf]

Dual Use Research – National Science Advisory Board for Biosecurity (NSABB)

A Companion Guide for Oversight of Life Sciences Dual Use Research of Concern [pdf]