Faculty and Staff
Phillip Buckhaults, Ph.D.
|Title:||Associate Professor / Drug Discovery and Biomedical Sciences
|College of Pharmacy|
Phillip Buckhaults is an experienced molecular biologist and cancer geneticists who has extensive experience with next-gen sequencing applications for global gene expression analysis and gene mutation detection.
He characterized the expression landscapes of colon tumors to identify signatures of recurrence and the mutation landscapes of breast and colon tumors to identify novel cancer genes, and he has profiled cancer gene mutation signatures in melanomas to determine novel therapeutic modalities based on targeting PI3K and BRAF pathways.
Buckhaults uses somatic cell knockout technology to characterized variant alleles in human cells and has discovered novel functions of a polymorphism in the TP53 gene.
The Buckhaults Lab Research Focus
- Determining biochemical mechanisms by which germline variants contribute to cancer health disparities that exist between people of different ethnic ancestries
- Using genome sequencing and functional genomics to develop novel personalized medicine approaches to treat colon cancer