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College of Engineering and Computing


Biomedical Engineering

Tissue Engineering

Carbon Nanotubes as Modulators of Extracellular and Transporters of Intracellular Cues

This study aims to generate a biologically adaptable device testbed for electromechanical pacing of stem cells, with the long-term goal of developing a new generation cell culture system that allows for diagnosis, monitoring and dynamic dialing of electromechanical signals to guide cell fate decisions.

Coronary Artery Bypass Grafting Analysis and Improvement

This project aims to improve vascular grafts prior to implantation using a provisionally patented bioreactor.

Decellularizing Tissue Engineering Scaffolds with Carbon Dioxide

This project is evaluating a novel decellularization method for preparing natural tissue engineering scaffolds using liquid or supercritical carbon dioxide.

Effects of Cyclical Strain on Elastin Production and Gene Expression in Tissue-engineered Constructs

This project investigates the influence of cyclical mechanical strain on the transcriptomic regulation of elastogenesis in tubular constructs fabricated from microcarriers containing vascular SMCs and endothelial cells, as well as the effects of mechanical pre-conditioning on matrix composition and architecture. 

Manifestation of “Optimal Mechanical Operation” in Vascular Tissue

This project is focused on understanding fundamental phenomenon in vascular tissue mechanics and extending findings towards the advancement of vascular therapies.

Modulation of Inflammatory Response for Accelerated Vascularization and Bone Regeneration

The goal of this study is to harness the potential of inflammatory response to enhance directed angiogenesis and osteointegration of three-dimensional scaffolds for bone repair.

Parsing the Effects of Physical Cues in Stem Cell Adhesion and Lineage Specification

This work uses the ability to control cell size and spreading of stem cells and the ability to adjust matrix elasticity to regulate stem cell lineage commitment.

The Role of Cell Shape and Orientation in Lineage Specification of Embryonic Stem Cells

The goal of this study is to generate and characterize a monolayer single-cell culture model that allows for the investigation of biological phenomena associated with human pluripotent stem cell lineage specification.