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College of Engineering and Computing


Biomedical Engineering

Biomechanics

Manifestation of “Optimal Mechanical Operation” in Vascular Tissue

This research project is focused on understanding fundamental phenomenon in vascular tissue mechanics and extending findings towards the advancement of vascular therapies.

Identifying Patient-specific Risk Factors for Large Vessel Ischemic Stroke

The project focuses on relating computed hemodynamic stresses acting on carotid atherosclerotic plaques, based on patient-specific CT images, to gene and protein expression levels in human endarterectomy specimens.

Biomechanics of Arterial Tissue Failure at Multiple Length Scales

The objective of this research project is to advance our understanding of mechanical failure mechanisms in arterial tissue, focusing on atherosclerotic plaque failure and arterial dissection.

Role of Hemodynamics in Cardiac Development

This project aims to investigate the impact that blood flow and mechanics have on influencing stem cell migration and the epithelial-mesenchymal transformation during cardiac development.

Mechanics of Large Arteries in Mouse Models of Vascular Disease

This project uses transgenic and surgical animal models to provide insight into different types of vascular abnormalities such as aortic aneurysms, hypertension, and atherosclerosis.

Coronary Artery Bypass Grafting Analysis and Improvement

This project aims to improve vascular grafts prior to implantation using a provisionally patented perfusion bioreactor.

Effects of Cyclical Strain on Elastin Production and Gene Expression in Tissue-engineered Constructs

This project investigates the influence of cyclical mechanical strain on the transcriptomic regulation of elastogenesis in tubular constructs fabricatedfrom microcarriers containing vascular SMCs and endothelial cells, as well as the effects of mechanical pre-conditioning on matrix composition and architecture. 

Mechanically Sensitive Three-dimensional Hydrogels and Drug Delivery

This project aims to improve vascular grafts by reducing mechanical mismatch between the grafted vessel and coronary circulation.