Faculty and Staff
|Title:||Associate Professor, School of Medicine, Biomedical Engineering
|Department:||School of Medicine, Biomedical Engineering
College of Engineering and Computing
School of Medicine
Ph.D., Anatomy/Cell Biology, University of Iowa, Iowa City, IA
B.A., Biology/Chemistry, Wartburg College, Waverly, IA
The prevalence of congenital cardiac malformations places an extreme sociological and personal burden. There are a myriad of congenital cardiac defects but the majority involve a region known as the atrioventricular canal (AV). The AV canal is responsible for the production of the AV valves and membranous portion of the interventricular septum. This is accomplished through a process known as "epithelial-mesenchymal cell transformation". Understanding how the early heart and in particular the AV canal is formed is critical to building the foundation for future therapeutic measures.
Norris, RA, Potts, JD, Yost, MJ, Junor, L, Brooks, T, Tan, H, Hoffman, S, Hart, MM, Damon, B, Markwald, RR, Goodwin, RL. 2009. Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cells. Dev. Dyn. 238:1052-1063.
Goldsmith, E, A Hoffman, A Jacobs, JP Watson and JD Potts. 2009. The collagen receptor DDR2 is a marker for the transformed phenotype produced during cardiac epithelial-mesenchymal cell transformation. Anatomical Record. EPub ahead of Print.
Nesbitt,T, Tan, H, Junor, L., Yost, M., Dettman, R., Franco-Roberts, A., Potts, JD, Goodwin, RL. 2009. Coronary endothelial proliferation and morphogenesis are regulated by a VEGF-mediated pathway. Dev Dyn. 238:423-430.
Valarmathi MT, Davis, J, Yost MJ, Goodwin RL, Potts JD. 2009. A Three-Dimensional Model of Vasculogenesis. Biomaterials. 30:1098-1112.