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College of Engineering and Computing


Faculty and Staff

Taixing Cui

Title: Assistant Professor
Department: Biomedical Engineering
College of Engineering and Computing
E-mail: taixing.cui@uscmed.sc.edu
Phone: 80-3216-3804
Fax: 803-216-3846
Office:

School of Medicine Bldg 4   
Room C-5   
6439 Garners Ferry Road   
Columbia, SC 29209

Education

Ph.D., Molecular Medicine, Ehime University School of Medicine, Japan, 2001

M.D., The Fourth Military Medical University, P.R.China, 1989

Research

The majority of cardiovascular  disease results from complications of vascular disorders, e.g., atherosclerosis  that becomes worse under the circumstance with obesity and diabetes. Dr. Cui  has a research interest in vascular biology with special reference to the  vasculopathy associated with obesity and diabetes. Dr. Cui's laboratory takes a  multi-disciplinary approach to address the molecular and cellular mechanism  that links obesity, diabetes and vascular disease, with a specific focus on the  role of ubiquitin-proteasome system in the maintenance of vascular  homeostasis.
There are four areas of technical  strengths in Dr. Cui's laboratory: 1) molecular biology including most of the  routine DNA, RNA and protein techniques; 2) cellular biology including primary  culture of vascular smooth muscle cells, endothelial cells, macrophages and  adipocytes, dissection of signal transduction pathways involved in cellular  metabolism, migration and proliferation as well as inflammatory responses; 3)  development and characterization of animal models of vascular disease through  transgenic approaches; 4) vascular physiology analyses in cell, organ and whole  animal levels.
Two major projects currently underway include:
Defining mechanism that regulates Keap1-mediated Nrf2 ubiquitination, degradation, anti-oxidative gene expression in vasculature.Determining mechanism that controls the deubiquitinating enzymes such as UCH-L1- or CYLD-mediated suppression of inflammatory responses in vasculature.
 

Publications

  • Cui T, Schopfer FJ, Zhang J, Chen K, Baker PRS, Feng X, Agarwal A, Freeman   BA, Chen YE. Nitrated Linoleic and Oleic acids; Endogenous Anti-inflammatory   Signaling Mediators J Biol Chem. 2006, 281:35686-98
  • Villacorta L, Zhang J, Schopfer FJ, Baker PRS, Freeman BA, Chen YE, Cui T.   Nitrated Linoleic acids inhibit proliferation of vascular smooth muscle cells   via Keap1/Nrf2 pathways. Am J Physiol. Heart Circ Physiol 2007,   293(1):H770-6
  • Takami Y, Nakagami H, Morishita R, Katsuya T, Cui T, Ichikawa T, Saito Y,   Hayashi H, Kikuchi Y, Nishikawa T, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda   Y. Ubiquitin Carboxyl-Terminal Hydrolase L1, a Novel Deubiquitinating Enzyme in   the Vasculature, Attenuates NF-?B Activation. Arterioscler Thromb Vasc Biol. 2007, 27(10):2184-90
  • Ichikawa T, Zhang J, Chen K, Liu Y, Schopfer FJ, Baker PRS, Freeman BA, Chen YE, Cui T. Nitroalkenes suppress   LPS-induced STAT signaling in macrophages: A critical role of MKP-1. Endocrinology 2008, 149(8):4086-4094